Dorly de Freitas Buchi

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Dorly de Freitas Buchi, a renowned Brazilian researcher, holds a Ph.D. in Biological Sciences (Biophysics) from the Federal University of Rio de Janeiro. Her solid academic background is reflected in the publication of several scientific articles in the field of Cell Biology. Professor, for more than 40 years at the Federal University of Paraná, she combines extensive experience in higher education, both in undergraduate and graduate courses, and effective contributions in the sphere of the university administration. Her orientation activities are remarkable, from scientific initiation to doctorate, having promoted the training of a large number of young scientists.

Despite this exemplary academic trajectory, what makes Dorly a special human being are her unique qualities: loyalty, courage, tenderness, and tenacity. Woman, mother, sister, and friend, she is endowed with profound sensitivity, a conciliatory spirit, and the ability to aggregate people and ideals around a greater good. Her respect for life, in all its forms, has always guided her in search of health promotion and a better life for all. And so, in her continuous overcoming of challenges, guided by an acute scientific curiosity and her non-conformity with the paradigms and limitations of traditional medicine, in an untiring spirit and an unwavering purpose of serving collective interests, firmly carried out research based on highly diluted drugs and complex biological response modifiers. A significant part of the results of her efforts and her holistic view is presented in this book which, as an author, proposes to contribute to life, health, and the construction of happiness for all.

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Immune System and Homeopathy Studies using macrophages treated with different homeopathic medicines have resulted in a significant increase in the activated/resident macrophage ratio compared to control groups (water, hydroalcoholic solution, and untreated). Different macrophage receptors were altered, both in expression and distribution, in addition to altering the production and release of different cytokines and reactive oxygen and nitrogen species…

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  • Like cures like: This principle states that a substance that can cause symptoms in a healthy person can cure those same symptoms in a sick person. For example, if a person gets a rash from contact with poison ivy, then a homeopathic remedy made from poison ivy might be used to treat a rash with similar symptoms.

  • The law of minimums: This principle states that the smaller the dose of a remedy, the greater its effect. Homeopathic remedies are often diluted to very high levels, but practitioners believe that this dilution makes them more effective.

  • The single remedy: This principle states that only one remedy should be given at a time, so that its effects can be clearly observed.

  • The totality of symptoms: This principle states that the remedy should be chosen based on the whole picture of the patient’s symptoms, not just the physical symptoms. This includes the patient’s emotional and mental state, as well as their lifestyle and preferences.

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The existence and unexpected pathways in my life.

In this book, I tell the story of my life and my relationship with science, and especially how this journey resulted in 20 years of basic research in homeopathy.

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PROTEINS THAT DEGRADE THE EXTRACELLULAR MATRIX, FACILITATING METASTASIS, ARE SUPPRESSED BY M1 AND M8

by | Mar 2, 2024 | homeopathy, science | 0 comments

PROTEINS THAT DEGRADE THE EXTRACELLULAR MATRIX, FACILITATING METASTASIS, ARE SUPPRESSED BY M1 AND M8


Metastasis is a multistep process driven by selective interactions that occur during circulation. Altered adhesion molecules, leading to changes in migration patterns, coupled with the high production of proteolytic enzymes, favors the degradation of the extra cellular matrix barrier, rendering the invasion of adjacent tissues possible. Therefore, our current hypothesis is that M1 and M8 may act directly on cancer cells, without cytotoxicity, suppressing the metastatic phenotype.


Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix (ECM) in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis, and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.


Both M1 and M8 reduced the activity of secreted MMP-2, 25.48% and 30.42%, respectively. Through different mechanisms, both M1 and M8 modulated key molecules (ROS, PDGF-B, surface adhesion molecules, and MMP-2) for the melanoma metastatic phenotype, leading to a reduction in the capacity of the cells to generate new colonies and invade other tissues.


The majority anti-cancer chemotherapeutics used clinically are cytotoxic, which causes severe side effects for patients, with limited effective results against metastatic melanoma.


MMP-2 is the main gelatinolytic enzyme in melanoma, mainly produced at the tumor edges, its invasive front. Therefore, the notable finding of ECM degradation reduction by HDNCs may contribute to the impairment of the capacity 0f tumor cells to escape and spread, thus reducing metastasis. Fortunately, it is currently known that molecules can be kept at the air-liquid interface in between dilutions and be carried to the next ones. Therefore, we can now understand high dilutions as a nanomedicine system.


We strongly believe that these complexes may help to increase the survival of patients with metastasis, with therapeutic use as one integrative and complementary therapy.


INTERNATIONAL JOURNAL OF ONCOLOGY 55: 721-732, 2019
DOI: 10.3892/ijo.2019.4846