SCIENCE is exploring the potential of INNATE IMMUNITY to benefit animal health. The rational basis of immunomodulation directed to the innate immune system is related to its ability to respond to a wide variety of pathogens, in contrast to specific therapies such as vaccines and antibiotics.

The innate immune response is responsible for trying to block the replication of pathogens before the onset of the disease. It is a rapid and nonspecific response involving a complex network of biochemical and cellular pathways, which actively recognize and remove invading pathogens, as well as activates the ADAPTIVE IMMUNE RESPONSE resulting in lasting protection. The innate immune response is also involved in tissue repair processes, such as healing and bone remodeling, as well as participating in the immunological control of emerging tumors and processes of inhibition of tumor progression. Thus, the modulation of innate immunity has the potential for preventive, therapeutic or adjuvant use.

Highly diluted natural drugs were studied in research centers in Brazilian universities. Several modulatory effects of the innate immune response have been observed in vitro and in vivo studies using animal models. These immunomodulatory actions have also been demonstrated in the human and veterinary medical clinic.

Inflammatory Breast Carcinoma Canine treated with oral medication (drops) and topical (gel). (A) Clinical signs of breast carcinoma prior to treatment. (B) After 7 days of treatment. (C) No clinical signs after 60 days of treatment.

Clinical case: Highly diluted natural drug (M 8) in the treatment of Mammary Inflammatory Carcinoma in dogs – Veterinary Hospital – UFPR

SILVA D.M. et al. Oral, topical, and inhalation of Calcarea carbonica derivative complex (M8) to treat

inflammatory mammary carcinoma in dogs. Int J High Dilution Res 2012, 11(40). Proceedings of the XXVI GIRI Symposium; 2012 Florence (Italy)